Products
NovaForm® Wound Matrix
Collagen–Bioglass Matrix for Advanced Wound Healing
NovaForm® Wound Matrix
Advanced Collagen–Bioglass Matrix for Optimal Wound Healing
NovaForm® Wound Matrix by Summit Products Group represents the next generation in wound care innovation. Designed as a porous combination of 20% bioglass and 80% bovine type I collagen, this fully resorbable matrix promotes natural healing and supports tissue regeneration. The absorbent device is supplied ready to hydrate and can be placed dry or pre-hydrated for convenience.
Clinically proven and backed by scientific evidence, NovaForm® has shown a noticeable reduction in deep wound bed inflammation in pre-clinical studies compared to other matrices. It is designed to break through regeneration roadblocks such as poor circulation, chronic inflammation, deep tissue loss, and overexpression of matrix metalloproteinases (MMPs)
Key Features
NovaForm® Collagen–Bioglass Matrix for Advanced Wound Healing
Advanced Collagen–Bioglass Matrix
Porous combination of 20% bioglass / 80% bovine type I collagen
Fully Resorbable Design
Fully resorbable (~30 days)
Ready-to-Use Flexibility
Supplied ready to hydrate (dry or pre-hydrated placement)
Clinically Proven Inflammation Reduction
Noticeable reduction in deep wound bed inflammation (porcine model vs. Endoform)
Demonstrated Biocompatibility
No evidence of irritation or sensitization in clinical study
NovaForm Advantages
How NovaForm® Addresses Regeneration Challenges
Chronic and hard-to-heal wounds can be complicated by biological barriers. As outlined in scientific studies, NovaForm® Collagen–Bioglass Matrix offers distinct material-based advantages designed to address these challenges
| Regeneration Roadblock | NovaForm® Advantage |
|---|---|
Poor circulation | Bioglass promotes angiogenesis, increasing blood flow to the wound site and supporting new tissue formation 2,3,4 |
Chronic Inflammation | Bioglass modulates inflammation to break the chronic wound cycle and advance to tissue regenerations5
Bioglass promotes angiogenesis, increasing blood flow to the wound site and supporting new tissue formation 2,3,4 |
Missin Tissue (deep wounds) | Bioglass promotes deposition of extracellular matrix proteins and formation of granulation tissue through the sustained release of calcium and silicon ions4 Porous collagen microstructure supports tissue regeneration6 |
Overexpression of matrix metalloproteinases (MMPs) | Bioglass modulates expression of MMPs, directing cellular activity toward regeneration4 Collagen serves as a sacrificial substrate for residual MMPs, protecting living tissue from proteolytic damage6 |
Regeneration Roadblock
NovaForm® Advantage
Poor circulation
Bioglass promotes angiogenesis, increasing blood flow to the wound site and supporting new tissue formation 2,3,4
Chronic Inflammation
Bioglass modulates inflammation to break the chronic wound cycle and advance to tissue regenerations5
Bioglass promotes angiogenesis, increasing blood flow to the wound site and supporting new tissue formation 2,3,4
Missin Tissue (deep wounds)
Bioglass promotes deposition of extracellular matrix proteins and formation of granulation tissue through the sustained release of calcium and silicon ions4 Porous collagen microstructure supports tissue regeneration6
Overexpression of matrix metalloproteinases (MMPs)
Bioglass modulates expression of MMPs, directing cellular activity toward regeneration4 Collagen serves as a sacrificial substrate for residual MMPs, protecting living tissue from proteolytic damage6
Scientific Evidence
Scientific Evidence Supporting NovaFORM Efficacy
Wound Healing
Wound Healing in Rat Model with 4555 Bioglass
Effect of powdered 45S5Bioglass on wound healing – rat model
SEM Analysis
SEM Analysis of NovaFORM Structure
SEM image of NovaFORM (scale bar: 200 μm)
Regeneration Roadblocks
Diabetic Rat Wound Healing: Quantitative & Visual Data
Diabetic rat wound study: macroscopic images and quantitative wound closure data (BG/SA is 45S5 bioglass with sodium alginate)
Wound Healing in Rat Model with 4555 Bioglass
Effect of powdered 45S5Bioglass on wound healing – rat model
SEM Analysis of NovaFORM Structure
SEM image of NovaFORM (scale bar: 200 μm)
Diabetic Rat Wound Healing: Quantitative & Visual Data
Diabetic rat wound study: macroscopic images and quantitative wound closure data (BG/SA is 45S5 bioglass with sodium alginate)
References
- Data on file
- Naseri, Shiva, William C. Lepry, and Showan N. Nazhat. “Bioactive glasses in wound healing: hope or hype?” Journal of Materials Chemistry B 5, no. 31 (2017): 6167-6174.
- Qi, Quan, Yanlun Zhu, Gang Liu, Zhize Yuan, Haiyan Li, and Qiang Zhao. “Local intramyocardial delivery of bioglass with alginate hydrogels for post-infarct myocardial regeneration.” Biomedicine & Pharmacotherapy 129 (2020): 110382.
- Li, Ying, Xin Zhang, Dan He, Zhijie Ma, Ke Xue, and Haiyan Li. “45S5 Bioglass® works synergistically with siRNA to downregulate the expression of matrix metalloproteinase-9 in diabetic wounds.” Acta Biomaterialia 145 (2022): 372-389.
- Dong, Xin, Jiang Chang, and Haiyan Li. “Bioglass promotes wound healing through modulating the paracrine effects between macrophages and repairing cells.” Journal of Materials Chemistry B 5.26 (2017): 5240-5250.
- Brett, David. “A review of collagen and collagen-based wound dressings.” Wounds 20, no. 12 (2008): 347-356.